Predictors of Intravenous Immunoglobulin (IVIG) Resistance in Children with Kawasaki Disease in Calabria Region, Italy

Use of Corticosteroid in Children with Unresponsiveness to Intravenous Immunoglobulin in Kawasaki Disease

Background Kawasaki Disease (KD) is a vasculitis with multi-organ involvementof unknown etiology; it is the most common cause of pediatric-heart diseases in developed countries. Treatment with Intravenous Immunoglobulin (IVIG) prevents coronary artery lesions; although there are some IVIG-resistant cases, combination therapy with corticosteroids and IVIG is one of the recommendations for treatm...

Resistance to intravenous immunoglobulin (IVIG) in Kawasaki disease: no influence of different IVIG lot utilisation.

Novel predictors of intravenous immunoglobulin resistance in Chinese children with Kawasaki disease.

BACKGROUND The purpose of this study was to develop a predictive scoring system to identify intravenous immunoglobulin resistance in children with Kawasaki disease, to implement additional therapies early in the course of their illness and prevent coronary artery lesions. METHODS We performed a retrospective review of children with Kawasaki disease treated within 10 days of fever onset. To id...

Factors Predicting Resistance to Intravenous Immunoglobulin and Coronary Complications in Kawasaki Disease: IVIG Resistance in Kawasaki Disease

https://e-kcj.org Downie et al.1) defined intravenous immunoglobulin (IVIG) resistance in patients with Kawasaki disease (KD) as any patient who receives a second dose of IVIG and had a fever (body temperature [BT] >38.0°C) since finishing the first IVIG dose (2 g/kg). In addition, patients who do not respond to IVIG (BT ≥37.5°C more than 24 hours after the end of IVIG infusion) seem to develop...

Predictors of nonresponse to intravenous immunoglobulin therapy in Kawasaki disease

PURPOSE It has been reported that 10% to 20% of children with Kawasaki disease (KD) will not respond to intravenous immunoglobulin (IVIG) treatment. In this study, we aimed to identify useful predictors of therapeutic failure in children with KD. METHODS We examined 309 children diagnosed with KD at the Kyungpook National University Hospital and the Inje University Busan Paik Hospital between...

Intravenous immunoglobulin therapy for older children with Kawasaki disease

The risk-benefit balance of the full dose intravenous immunoglobulin (IVIG) infusion of 2 g/kg body weight/dose in older children has not been established. In this study, I investigated the safety and efficacy of this therapy for older children. In total, I recruited 210 children who had received 2 g/kg/dose of IVIG therapy for Kawasaki disease between 1999 and 2015 at the Department of Pediatr...